JAK2 Monoclonal Antibody, 50ul Sampling Tubes Ligand binding causes a conformation

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors

The protein (ankyrin repeat domain 1) encoded by ANKRD1 is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation

SEPT3 belongs to the septin family of GTPases

Other variants may also exist

which overlaps in some cases

JAK2 Monoclonal Antibody, 50ul Sampling Tubes Ligand binding causes a conformationThis gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.