CDKN3 Polyclonal Antibody, 50ul[BT-AP07568] Long RNA Synthesis Two modes of SLAM signaling

Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

but shuttles into the nucleus where it localizes to nuclear speckles

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells

Defects in this gene result in Senior-Loken syndrome type 5

The amino-terminal region is protease resistant and globular in shape

CDKN3 Polyclonal Antibody, 50ul[BT-AP07568] Long RNA Synthesis Two modes of SLAM signalingThe protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this