SLP-76(Phospho-Ser376) Rabbit Polyclonal Antibody, 100ul Immunology Alternate splicing results in several

Alternate splicing results in several transcript variants

The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities

This gene encodes a member of the GIT protein family| which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity

and is associated with spinocerebellar ataxia type 1 (SCA1)

Alternatively spliced transcript variants encoding different isoforms have been found for CDH18

SLP-76(Phospho-Ser376) Rabbit Polyclonal Antibody, 100ul Immunology Alternate splicing results in severalSLP 76 was originally identified as a substrate of the ZAP 70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP 76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2 terminus contains an acidic