Stat3 Polyclonal Antibody, 100ul[BT-AP01664] Protein Modification The protein functions as a

The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals

Mutations in CTSA are associated with galactosialidosis

An important paralog of this gene is SYNE2

Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm

RNA splicing

Stat3 Polyclonal Antibody, 100ul[BT-AP01664] Protein Modification The protein functions as aThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors STAT family members are phosphorylated by the receptor associated kinases and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs EGF IL5 IL6 HGF LIF and BMP2.