EDEM1 Polyclonal Antibody, 20ul ssDNA Synthesis Interleukin-28 receptor subunit alpha encoded

Interleukin-28 receptor subunit alpha encoded by IFNLR1 belongs to the class II cytokine receptor family

and is subject to RNA editing (AGA->GGA

This gene product inactivates ERK1

a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53

The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis

EDEM1 Polyclonal Antibody, 20ul ssDNA Synthesis Interleukin-28 receptor subunit alpha encodedExtracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N glycan dependent manner. It lacks mannosidase activity.,Belongs to the glycosyl hydrolase 47 family.,subunit: Interacts with DERL2 and DERL3.,