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The following confounding factors, i.e., gender, age, blood lactate level on admission, plasma VPA concentration on admission and SOFA score on admission were included in the propensity score calculation

In summary, the failure of the endogenous antioxidant defense system allows the massive oxidative insult to trigger a complex array of downstream pathological consequences, including robust inflammatory responses, multiple forms of cardiomyocyte death, and widespread disruption of vital signaling networks

Local tissue responsesincluding inflammation, fibrosis, infection risk, and unintended tissue remodelingmust be rigorously assessed, particularly because the pelvic environment is highly sensitive and anatomically complex