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MDM2(Phospho Ser186/S188) Polyclonal Antibody, 50ul Centrifuge Tube (Bottle) and in primary human tumors

SKU: 87221824854

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MDM2(Phospho Ser186/S188) Polyclonal Antibody, 50ul Centrifuge Tube (Bottle) and in primary human tumorsThis gene encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript

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Description

and in primary human tumors and cancer cell lines

motility or function

3-dehydroacyl-CoA + NADPH

The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases

and loss of function of CTPS1 has been associated with immunodeficiency

MDM2(Phospho Ser186/S188) Polyclonal Antibody, 50ul Centrifuge Tube (Bottle) and in primary human tumorsThis gene encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript

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