Rb Polyclonal Antibody, 50ul[BT-AP07693] Cell Transfection Five alternatively spliced transcript variants

Five alternatively spliced transcript variants encoding distinct isoforms have been reported

It may play an important role in ureagenesis and gluconeogenesis

It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins

Functional studies in mice determined that this protein plays a role in vestibular morphogenesis

rheumatoid arthritis

Rb Polyclonal Antibody, 50ul[BT-AP07693] Cell Transfection Five alternatively spliced transcript variantsThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.