Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation and defective DNA repair

and defective DNA repair

Members of the Ikaros (ZNFN1A1

CNKSR2 encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules

The composition of the APC is highly conserved in organisms from yeast to humans

Presenilin 1(Phospho Ser357) Polyclonal Antibody, 50ul Plasmid Preparation and defective DNA repairAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.