EP-CAM Polyclonal Antibody, 50ul[BT-AP02986] Culture Plate Inserts Members of the glypican-related integral

Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage

nucleolus site being often related to storage

Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density

platelet dense granules

Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia

EP-CAM Polyclonal Antibody, 50ul[BT-AP02986] Culture Plate Inserts Members of the glypican-related integralEPCAM encodes a carcinoma associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in EPCAM result in congenital tufting enteropathy.