Human Matrix Metalloproteinase-16, MMP16 ELISA Kit , 96T Sample Library Tubes May contribute to catalysis through

May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme

May also play a role in neovascularization or angiogenesis

an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 12297508

SURF1 encodes surfeit locus protein 1 localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex

Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus

Human Matrix Metalloproteinase-16, MMP16 ELISA Kit , 96T Sample Library Tubes May contribute to catalysis throughEndopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.