MYCN Polyclonal Antibody, 20ul Cell Function Analysis Mutations in this gene can

Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus

The integrin subunit alpha 2 forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix

suggesting that it may play a role in regulating genes in germ cells

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al

MYCN Polyclonal Antibody, 20ul Cell Function Analysis Mutations in this gene canThis gene is a member of the MYC family and encodes a protein with a basic helix loop helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.