PAK Alpha Polyclonal Antibody, 50ul[BT-AP06894] Microplate Mixer TMEM145 (transmembrane protein 145) is

TMEM145 (transmembrane protein 145) is a 493 amino acid protein encoded by a gene mapping to human chromosome 19

Lysophosphatidic acid receptor 5 transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes

which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization

While several transcript variants may exist for this gene

The GNL1 gene is located less than 2 kb centromeric to HLA-E

PAK Alpha Polyclonal Antibody, 50ul[BT-AP06894] Microplate Mixer TMEM145 (transmembrane protein 145) isPAK1 encodes a family member of serine threonine p21 activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology.