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EGFL5 Polyclonal Antibody, 100ul Apoptosis & Autophagy The protein encoded by this

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EGFL5 Polyclonal Antibody, 100ul Apoptosis & Autophagy The protein encoded by thisMEGF9 (Multiple EGFlike domains protein 9; also EGFlike protein 5) is a 63 kDa (predicted) novel transmembrane glycoprotein that shares some homology to beta chains of laminin. It is expressed by hepatocytes, cerebellar Purkinje cells, Schwann cells, keratinocytes and intestinal epithelium. MEGF9 is suggested to participate in cell motility, and its absence correlates with tumor cell migration. Mature human MEGF9 is 572 amino acids (aa) in length. It

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Description

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration

The protein localizes primarily to the nucleus and its expression is developmentally regulated

Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin

Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues

1N have been reported to detect mulitple forms

EGFL5 Polyclonal Antibody, 100ul Apoptosis & Autophagy The protein encoded by thisMEGF9 (Multiple EGFlike domains protein 9; also EGFlike protein 5) is a 63 kDa (predicted) novel transmembrane glycoprotein that shares some homology to beta chains of laminin. It is expressed by hepatocytes, cerebellar Purkinje cells, Schwann cells, keratinocytes and intestinal epithelium. MEGF9 is suggested to participate in cell motility, and its absence correlates with tumor cell migration. Mature human MEGF9 is 572 amino acids (aa) in length. It

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