Again, subtraction is useful in cases like this: Gd-induced signal increase over the already very bright pre-contrast image would be very hard to appreciate otherwise
There is substantial evidence that the expression of SOCS3 protein increases with aging in several cells/tissues, such as rat myocardium [162], hypothalamus [163], and human blood mononuclear cells [164] as well as human sarcopenic skeletal muscles [165] and the brains of Alzheimers patients [166]
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Although both type 1 and 2 5 -reductases are expressed in prostate tumor cells 28 , and the administration of 5 -reductase inhibitor alone or in combination with androgen antagonist inhibits prostate tumor cell growth in culture 88 , 89 , the efficacy of finasteride in the treatment of prostate cancer is disappointed 90
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