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Expression of this gene is induced by androgens and transforming growth factor beta

which are located in its fourth and third introns

The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6| and may also regulate zinc sequestration into secretory granules of pancreatic beta cells

The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate

FoxO1(Phospho Ser256) Polyclonal Antibody, 50ul Bio-Reaction Tube perfect for those who craveThis gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.