PROTAC SGK3 degrader-1 ne Fendizoate is a novel aniline compound

is a novel aniline compound

2016 Sep 6

InChiKey: XTKDQPFUOFAMRL-UHFFFAOYSA-N

a serine/threonine protein kinase overexpressed in certain types of cancer cells

the combination of Dasatinib and GNF-2 overcame resistance of BCR/ABL-T315I in all models used in a synergistic manner

PROTAC SGK3 degrader-1 ne Fendizoate is a novel aniline compoundPROTAC SGK3 degrader 1 (SGK3 PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader 1 (0. 3 M) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate). Product information CAS Number: 2381320 35 8 Molecular Weight: 1157. 38 Formula: C57H73FN10O11S2 Chemical Name: (2S, 4R) 1 [(2S) 2 (2 {2 [2 ({6 [(2R) 2 [({6