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Cellular senescence is characterized by a stable arrest in the cell cycle and encompasses a range of cellular changes that culminate in the development of a complex, pro-inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP), which plays a critical role in fibrosis and tumors by affecting numerous processes, including invasion and therapy resistance 10

doi: 10.1056/NEJMoa1802670 31 IankovaI.Thompson-LeducP.KirsonN

The more energy required for a chemical activity, the more ATP molecules must be spent

Rapid weight loss can lead to various side effects, like fatigue, gastrointestinal problems, hair loss, changes in facial appearance, visible signs of premature aging, digestive issues, reduced muscle mass and bone density, and mental health issues such as depression and anxiety

The membrane of erythrocytes comprises of proteins (50%), lipids (40%), and carbohydrates (10%)

Around one-third of patients achieved 25% or greater weight loss