AZD-5438 Size:Solid 2 mg Potent and Selective Triazole-Based Inhibitors

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

[3] Bepotastine (100 μM) dose-dependently inhibits chemotaxis of cultured guinea pig peritoneal eosinophils induced by LTB4

the major inhibitory neurotransmitter in the central nervous system by blocking the GABA transporter and hence is classified as a GABA reuptake inhibitor

Losartan D4 Carboxylic Acid (E-3174 D4) is the deuterium labeled Losartan(EXP-3174)

which is an angiotensin converting enzyme (ACE) inhibitor

AZD-5438 Size:Solid 2 mg Potent and Selective Triazole-Based InhibitorsAZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.