Erastin syl-L-homocysteine (SAH) PAI-039 is a small-molecule inhibitor

PAI-039 is a small-molecule inhibitor of PAI-1 activity

Betamethasone hydrochloride is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities

Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma

Formula: C28H44O

1 μM and 27 μM

Erastin syl-L-homocysteine (SAH) PAI-039 is a small-molecule inhibitorErastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i. e. HRAS, KRAS). Erastin produces non apoptotic tumor cell death by altering mitochondrial voltage dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized