EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid GSK3235025

GSK3235025

Chemical Name: N-(2-aminophenyl)pyrazine-2-carboxamide

BG45 alone and in combination with bortezomib triggers significant tumor growth inhibition in vivo in a murine xenograft model of human MM

DASA-58 (40 μM) treated cells are injected into male SCID-bg/bg mice bearing PC3 tumors by IV

Molecular Weight: 433

EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid GSK3235025EPZ015666, also known as GSK3235025, CAS No. 1616391 65 1, is a potent and selective and orally active PRMT5 inhibitor with a half maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases. Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death, with IC50 values in the nanomolar range. Oral dosing with EPZ015666 demonstrated dose dependent