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AZD-2281 - CAS# 763113-22-0 308 It has ~125-fold greater selectivity

AZD-2281 - CAS# 763113-22-0 308 It has ~125-fold greater selectivity

Name: AZD-2281 - CAS# 763113-22-0 308 It has ~125-fold greater selectivity
Brand: clickpoint.com.au
SKU: 14287317212
Price: 55.00 USD
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SKU: 14287317212

4.1

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AZD-2281 - CAS# 763113-22-0 308 It has ~125-fold greater selectivityAZD 2281, also known as Olaparib or KU 59436, CAS No. 763113 22 0, is a small molecule inhibitor of the nuclear enzyme poly(ADP ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. AZD 2281 selectively binds to and inhibits PARP, inhibiting PARP mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA damaging agents and may reverse tumor cell

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Description

It has ~125-fold greater selectivity over UCH-L1 (ubiquitin C-terminal hydrolase L1

Solubility: DMSO and water up to 50 mM

288(15):10684-91

with EC50s of 0

12 cells (EC50 ~261 nM) and H146 ALL cells (EC50 ~4

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