Cyclopamine - Hedgehog Antagonist. CAS# 4449-51-8 60317 Cyclopamine-mediated hedgehog pathway inhibition depletes

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

InChiKey: YEVOZZZLKJKCCD-UHFFFAOYSA-N

a BET bromodomain inhibitor now in clinical development

Smiles: OC(=O)CCC1=C(NC2=CC(Cl)=CC(Cl)=C12)C(O)=O

Currently CI994 is in phase III clinical trials for lung cancer

Cyclopamine - Hedgehog Antagonist. CAS# 4449-51-8 60317 Cyclopamine-mediated hedgehog pathway inhibition depletesCyclopamine, CAS No. 4449 51 8, is a potent and selective inhibitor of the hedgehog signaling with an IC50 ~46 nM, acting as an antagonist of Smoothened. It is a natural product isolated from the corn lily (Veratrum californicum). As the hedgehog signaling pathway plays very important roles in embryogenesis and cancer progression, Cyclopamine has been used in stem cell differentiation, such as pancreatic cell differentiation from ESC iPSC, or treating