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Those covered through Medicare Part D may be able to get Foundayo for $50 per month, starting as soon as July 1, 2026

GLP-1 medications like semaglutide primarily cause digestive issues as your body adjusts to slower stomach emptying

The company sees retatrutide as a successor to its fast-growing dual GIP/GLP-1 agonist Zepbound/Mounjaro (tirzepatide) now the top-selling weight-loss drug worldwide and also as a companion to new oral GLP-1 agonist Foundayo (orforglipron) as it battles for market share with main rival Novo Nordisk

Additionally, the process of fasting before surgery can also impact your glucose regulation

This cycle also creates frustration and psychological barriers to adherence, as patients lose progress and face renewed appetite struggles repeatedly

GLP-1 receptor agonists slow gastric emptyingthe rate at which food leaves your stomachwhich can trigger nausea, dehydration, and electrolyte shifts