JW74 - CAS# 863405-60-1 0073 25(2):226-42

25(2):226-42

Umifenovir (45-180 mg/kg

Chemical Name: 5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide

1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]ethanol

Pirinixic acids: flexible fatty acid mimetics with various biological activities

JW74 - CAS# 863405-60-1 0073 25(2):226-42JW74, CAS No. 863405 60 1, is a tankyrase specific inhibitor. JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. At the molecular level, JW74 induces stabilization of AXIN2, a key component of the catenin destruction complex, resulting in reduced levels of nuclear catenin. At the functional level, JW74 induces reduced cell growth in all three tested cell lines, in part due to a delay in cell cycle