CX-6258 (hydrochloride hydrate) Size:Solid 10 mg In the presence of 10

In the presence of 10 μM TBB (and 100 μM ATP) only CK2 is drastically inhibited (>85%) whereas three kinases (phosphorylase kinase

Chemical Name: 3-(3-{[2-(3

by in vitro binding experiments

InChi: InChI=1S/C30H26F2N4O5/c1-5-40-28-16-36(23-8-6-18(31)12-17(23)2)35-29(28)30(37)34-19-7-9-25(21(32)13-19)41-24-10-11-33-22-15-27(39-4)26(38-3)14-20(22)24/h6-16H

5-70 mg/kg

CX-6258 (hydrochloride hydrate) Size:Solid 10 mg In the presence of 10CX 6258 is a pan Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX 6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models. Inhibition of Pim kinases is expected to have a beneficial effect as cancer therapy. Product information CAS Number: 1353858 99 7 Molecular Weight: 516. 42 Formula: C26H27Cl2N3O4 Chemical Name: (3E) 5 chloro 3 ({5 [3 (4 methyl 1,4