ABT-100 - CAS# 450839-40-4 60183 Pardoprunox

Pardoprunox

9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid

autophagy and cellular senescence during Osteoarthritis (OA)

is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia

Pomalidomide 4PEG2acid

ABT-100 - CAS# 450839-40-4 60183 PardoprunoxABT 100, CAS No. 450839 40 4, is an orally bioavailable farnesyltransferase inhibitor. ABT 100 inhibited proliferation of cells in vitro carrying oncogenic H Ras (EJ 1 bladder; IC(50) 2. 2 nmol L), Ki Ras (DLD 1 colon, MDA MB 231 breast, HCT 116 colon, and MiaPaCa 2 pancreatic; IC(50) range, 3. 8 9. 2 nmol L), and wild type Ras (PC 3 and DU 145; IC(50), 70 and 818 nmol L, respectively) as well as clonogenic potential. ABT 100 shows 70% to 80% oral