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These negative effects can ultimately lead to an increased risk or progression of the diseased state of many degenerative diseases, such as diabetes, rheumatoid arthritis, cancer, and aging

Side effects generally scale with dose increases

In accordance, targeting of NRF2 is of high interest, due to its prominent roles in several neurodegenerative hallmarks

Although liver biopsy is not routinely required, it may be useful in diagnostically uncertain cases

The oval cells of liver, which are considered to be the equivalent of progenitor cells in the liver, may potentially be propagated in vitro and used restoratively in some liver diseases

Retrieved 14 May 2011