CEP-37440 nalog-1 and prednisolone with wild-type and

and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100

Inhibition was observed at heteromeric ASIC channels

InChiKey: CAANPUBZFFRWQP-UHFFFAOYSA-N

¹³]trideca-2

inhibition and pH-dependent studies revealed that the sulfoxidn

CEP-37440 nalog-1 and prednisolone with wild-type andCEP 37440 is an orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK FAK inhibitor CEP 37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK and FAK mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK and FAK