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About this article Cite this article Hafezi, M., Arabipoor, A., Ghaffari, F

Melatonin can interact with various medications, and patients should always inform their healthcare providers about all medications and supplements they are taking

Upon binding to IGF-1, IGF-1 receptor (IGF-1R) phosphorylates an intracellular adaptor protein insulin receptor substrate-1 (IRS-1), which recruits and phosphorylates phosphoinositide 3-kinase (PI3K) followed by Akt phosphorylation