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INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate CAS Number: 290297-26-6

INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate CAS Number: 290297-26-6

Name: INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate CAS Number: 290297-26-6
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INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate CAS Number: 290297-26-6INCB3284 is a potent, selective, and orally bioavailable hCCR2 Antagonist. INCB3284 exhibited an IC50 of 3. 7 nM in antagonism of monocyte chemoattractant protein 1 binding to hCCR2, an IC50 of 4. 7 nM in antagonism of chemotaxis activity, an IC50 of 84 M in inhibition of the hERG potassium current, a free fraction of 58% in protein binding, high selectivity over other chemokine receptors and G protein coupled receptors, and acceptable oral

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Description

CAS Number: 290297-26-6

CAS Number: 87-51-4

SAR7334 inhibited TRPC6

with inhibition of proliferation and invasion of MDA-MB-231 non-IBC cells at higher concentrations

its mechanism of action is to modulate subunits

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