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Case reports don't prove causality, because you don't know if that person would have developed pancreatitis otherwise, said Ronald Goldenberg, a consultant endocrinologist emeritus at LMC Diabetes & Endocrinology who was involved in some of the earliest clinical trials testing GLP-1 drugs

These aggregates affect neuronal proteostasis, inhibit axonal transport, and interfere with mitochondrial and lysosomal function, resulting in oxidative stress, neuroinflammation, and apoptosis in susceptible neuronal populations [7]

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This is seen during aging and in individuals with psychiatric disorders 90,91,92

AKT/mTOR, serine/threonine protein kinase/Mammalian Target of Rapamycin