RN-1 - LSD1 Inhibitor. CAS# 1781835-13-9 size:10mg solid (2013) Biochem J

(2013) Biochem J

demonstrates both potential opportunity and possible challenges to therapeutic agonism

(2008) Biochem J

pharmacodynamic

Pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma

RN-1 - LSD1 Inhibitor. CAS# 1781835-13-9 size:10mg solid (2013) Biochem JRN 1, CAS No. 1781835 13 9, is a potent, specific and brain penetrant Lysine Specific Demethylase 1 (LSD1) inhibitor. RN 1 inhibits LSD1 in biochemical assay with an IC50 ~70 nM, and has weaker activity against monoamine oxidase proteins MAO A and MAO B with IC50 ~0. 51 M and 2. 79 M respectively. It exhibits good brain penetration and retention following systemic administration. RN 1 can abolish long term memory formation without affecting short term