CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0273 modulates Th1 differentiation in CD4(+)

modulates Th1 differentiation in CD4(+) T cells from patients with rheumatoid arthritis

PRT4165 was used at 10-50 µM final concentration in various in vitro assays

InChi: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18

a potent and selective inhibitor of polo-like kinase 1

suggesting potentially a long-lasting effect of S3I-201 on tumor growth

CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0273 modulates Th1 differentiation in CD4(+)CP 690550, CAS No. 477600 75 2, is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. It inhibits recombinant human JAK1 (IC50 ~ 3. 2 nM), JAK2 (IC50 ~4. 1 nM), and JAK3 (IC50 ~1. 6 nM). In cellular assays CP 690550 showed potent effects in the IL 2 blast proliferation assay (IC50 ~11 nM, mediated via JAK1 and JAK3) and HU03 cellular specificity assay (IC50 ~324 nM,