LXR-623 5363 Application of the nuclear factor-kappaB

Application of the nuclear factor-kappaB inhibitor Bay11-7085 for the treatment of endometriosis: an in vitro study

Chemical Name: hexasodium (1R

structural determination and biological activities

InChiKey: NCJPFQPEVDHJAZ-UHFFFAOYSA-N

CAS Number: 1397255-09-2

LXR-623 5363 Application of the nuclear factor-kappaBLXR623, also known as WAY 252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR( ) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY 252623 significantly reduced total (50 55%) and LDL cholesterol (LDLc) (70 77%) in a time and dose