Irbesartan rthenolide((-)-Parthenolide) It has a novel triazolotriazine

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Irbesartan rthenolide((-)-Parthenolide) It has a novel triazolotriazineIrbesartan, also known as BMS 186295, is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. It selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by adrenal cortex, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth

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