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PF-8380 Catalog No.:M10681-10 PubMed PMID: 17633123

PF-8380 Catalog No.:M10681-10 PubMed PMID: 17633123

Name: PF-8380 Catalog No.:M10681-10 PubMed PMID: 17633123
Brand: clickpoint.com.au
SKU: 56576659099
Price: 108.90 USD
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SKU: 56576659099

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PF-8380 Catalog No.:M10681-10 PubMed PMID: 17633123PF 8380 is a potent autotaxin inhibitor with an IC(50) of 2. 8 nM in isolated enzyme assay and 101 nM in human whole blood. PF 8380 has adequate oral bioavailability and exposures required for in vivo testing of autotaxin inhibition. Autotaxin's role in producing LPA in plasma and at the site of inflammation was tested in a rat air pouch model. The specific inhibitor PF 8380 , dosed orally at 30 mg kg, provided >95% reduction in both plasma and air

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Description

PubMed PMID: 17633123

Salas-Puig X

Solubility: DMSO : 100 mg/mL (1046

PD146176 (80 mg/kg

Smiles: CC(C)N(C1=CC=C(F)C=C1F)C(=O)N1C=NN(C2=CC=C(Cl)C=C2Cl)C1=O

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