VX-222 cis - CAS# 1026785-59-0 Catalog No.:M10875-2 unfolded protein accumulation leads to

unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α

Reduced methylene Blue dihydrobromide

4-tetrahydroquinolin-6-yl]benzoic acid

also known as ST1926

Biomol Ther (Seoul)

VX-222 cis - CAS# 1026785-59-0 Catalog No.:M10875-2 unfolded protein accumulation leads toLomibuvir, also known as VX 222, VCH 222 and VX22, is an nonnucleoside NS5B polymerase inhibitor. VX 222 inhibits the 1b Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) 5 nM. VX 222 binds to the HCV polymerase with dissociation constants of 17 nM. In phase 1 and 2 clinical studies, VX 222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1