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doi:10.1002/14651858.CD010287.pub3 Tsiami AP, Goulis DG, Sotiriadis AI, Kolibianakis EM

Rodent studies using metal oxide and silver nanoparticles have shown that high experimental doses of such materials can induce oxidative stress and inflammatory responses in the liver and gut, although these doses far exceed typical human dietary exposures (203207)

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Jin Q, Cirelli JA, Park CH, et al

However, research strongly suggests low B12 levels as a factor in NTDs, which isnt surprising, since folate and B12 work hand in hand