Crizotinib Hydrochloride - CAS# 1415560-69-8 Catalog No.:M10974-2 HI-TOPK-032 strongly suppressed TOPK kinase

HI-TOPK-032 strongly suppressed TOPK kinase activity but had little effect on extracellular signal–regulated kinase 1 (ERK1)

HSP90 or the 53 kinases tested

by activating a certain family of voltage-gated potassium channels in the brain

Orexin antagonists have multiple potential clinical applications including the treatment of drug addiction

InChi: InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10

Crizotinib Hydrochloride - CAS# 1415560-69-8 Catalog No.:M10974-2 HI-TOPK-032 strongly suppressed TOPK kinaseCrizotinib (PF 02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c Met and nucleophosmin (NPM) anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0. 025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Product information CAS Number: 1415560 69 8