GRP-60367 - CAS# 1309241-34-6 072 Protein cross-linking as a novel

Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity

with an IC50 of 6

GSK269962 can become an alternative worth considering in OAB treatment

424(1):47-60

Ogasawara K

GRP-60367 - CAS# 1309241-34-6 072 Protein cross-linking as a novelGRP 60367, CAS No. 1309241 34 6, is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP 60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell to cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a