![NMS-873 - ATPase VCP/p97 Inhibitor. CAS# 1418013-75-8 0321 Smiles: CC(C)(C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CC=C2NC1=O)C(=O)NCC(F)(F)C(F)(F)F](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/xcessbio1409714578.7818014.png?v=1742949463)
NMS-873 - ATPase VCP/p97 Inhibitor. CAS# 1418013-75-8 0321 Smiles: CC(C)(C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CC=C2NC1=O)C(=O)NCC(F)(F)C(F)(F)F
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NMS-873 - ATPase VCP/p97 Inhibitor. CAS# 1418013-75-8 0321 Smiles: CC(C)(C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CC=C2NC1=O)C(=O)NCC(F)(F)C(F)(F)FNMS 873, CAS NO. 1418013 75 8, is a potent and specific small molecule allosteric inhibitor of the ATPase VCP p97 (IC50 ~0. 03 M), identified by a high throughput screening. It is very selective (IC50 >10 M) against all of the AAA ATPases, HSP90 or the 53 kinases tested. Using photo affinity labeling, structural analysis and mutagenesis, the binding site of NMS 873 was found to be a region spanning the D1 and D2 domains of adjacent protomers
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