![GSK-J1 lithium salt ethyl Ivabradine Hydrochloride Smiles: CC(C)(C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CC=C2NC1=O)C(=O)NCC(F)(F)C(F)(F)F](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M8590_1621503862.gif?v=1630285269)
GSK-J1 lithium salt ethyl Ivabradine Hydrochloride Smiles: CC(C)(C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CC=C2NC1=O)C(=O)NCC(F)(F)C(F)(F)F
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GSK-J1 lithium salt ethyl Ivabradine Hydrochloride Smiles: CC(C)(C(=O)N[C@H]1C2=CC=CC=C2C2=CC=CC=C2NC1=O)C(=O)NCC(F)(F)C(F)(F)FGSKJ1 is a selective and potent histone demethylase inhibitor (GSK J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK J4: 1 M < IC50 < 10 M; e. g. 9 M in primary human macrophages). The pyridine regio isomer GSK J2 displays significantly less on target activity (IC50 > 100 M for human JmjD3) and thus can be used as control for target effects in vitro, and as ester derivative (GSK J5) in
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