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UNC0379 - Lysine Methyltransferase SETD8 Inhibitor. CAS# 1620401-82-2 002ompound Library of Histone Methyltransferase and has slight activity against

UNC0379 - Lysine Methyltransferase SETD8 Inhibitor. CAS# 1620401-82-2 002ompound Library of Histone Methyltransferase and has slight activity against

Name: UNC0379 - Lysine Methyltransferase SETD8 Inhibitor. CAS# 1620401-82-2 002ompound Library of Histone Methyltransferase and has slight activity against
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UNC0379 - Lysine Methyltransferase SETD8 Inhibitor. CAS# 1620401-82-2 002ompound Library of Histone Methyltransferase and has slight activity againstUNC0379, CAS No. 1620401 82 2, is a selective, substrate competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies. Importantly, UNC0379 is selective for SETD8 over 15 other methyltransferases. The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes

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Description

and has slight activity against HDAC8 (IC50 ~0

Repeat administration of AS2034178 enhanced insulin sensitivity in an insulin tolerance test and a euglycemic-hyperinsulinemic clamp test

Formula: C21H17N3O2S

=95% (NMR)

(2017) Cancer Lett

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