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RI-1 - CAS# 415713-60-9 ihydrochloride InChi: InChI=1S/C19H17N9O5S2/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27/h2-6

RI-1 - CAS# 415713-60-9 ihydrochloride InChi: InChI=1S/C19H17N9O5S2/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27/h2-6

Name: RI-1 - CAS# 415713-60-9 ihydrochloride InChi: InChI=1S/C19H17N9O5S2/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27/h2-6
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RI-1 - CAS# 415713-60-9 ihydrochloride InChi: InChI=1S/C19H17N9O5S2/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27/h2-6RI 1 is an irreversible inhibitor of RAD51 (IC50s = 5 30 M), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI 1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI 1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into

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Description

InChi: InChI=1S/C19H17N9O5S2/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27/h2-6

(2011) Int J Oncol

Epub 2019 Jun 18

also known as S-4661 and Finibax

it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3)

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