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The co-primary endpoints, percent change in body weight from baseline and proportion of patients achieving 5% weight loss, were identical to those of SURMOUNT-1, as were the two estimands: the TRE (which included all patients who were randomized) and the efficacy estimand (which included randomized patients who remained on the study treatment for the entire efficacy assessment duration of the trial)

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The studies featured follow-up periods ranging from 6 to 12 months and measured outcomes including on-treatment weight loss, HbA1c changes, and heterogeneous cardiovascular events (e.g., all-cause mortality, myocardial infarction, and stroke)

Sarwer, PhD, director of the Center for Obesity Research and Education, Temple University, and a spokesperson for the Obesity Society who wasnt involved in the research

Abstract The use of gut-hormone receptors agonists as new therapeutic options for obesity and some of its related comorbidities, such as type 2 diabetes, has resulted in an unprecedented efficacy in the medical management of people living with obesity (PLWO)

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