Pacritinib - CAS# 937272-79-2 adib) Chemical Name: 3-[3-({[(7S)-3

Chemical Name: 3-[3-({[(7S)-3

Pharmacological brake-release of mRNA translation enhances cognitive memory

InChiKey: RZTAMFZIAATZDJ-UHFFFAOYSA-N

37)38/h1-9

The combination of inhibitory activities on independent kinase and bromodomain oncogenic pathways exemplifies a new strategy for rational single-agent polypharmacological targeting

Pacritinib - CAS# 937272-79-2 adib) Chemical Name: 3-[3-({[(7S)-3Pacritinib, also known as SB1518, is a n orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK STAT signaling pathway, and so caspase dependent apoptosis. JAK2 is the most common mutated gene in bcr abl negative myeloproliferative disorders; the JAK2V617F gain of