SCH900776 Size:Solid 10 mg Co-culture of hepatocellular carcinoma cells

Co-culture of hepatocellular carcinoma cells and human umbilical endothelial cells damaged by SU11274

Chemical Name: {[(3Z)-4-{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamido}-3-[(Z)-benzoylsulfanyl]pent-3-en-1-yl]oxy}phosphonic acid

PubMed PMID: 30101119

5-e]azepin-4-yl)acetamide

also known asCX 295

SCH900776 Size:Solid 10 mg Co-culture of hepatocellular carcinoma cellsSCH900776, also known as MK 8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1 dependent cell cycle arrest in the S and G2 M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA damaging effects of ionizing