E6446 oxyguanosine 71(23):7238-49

71(23):7238-49

Chemical Name: 2-(furan-2-ylmethylsulfinyl)-N-[(Z)-4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]acetamide

Moscarella E

antiproliferative activity

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

E6446 oxyguanosine 71(23):7238-49E6446 inhibits Toll like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine phosphate guanidine (CpG) containing DNA, which stimulates TLR9. Product information CAS Number: 1219925 73 1 Molecular Weight: 449. 59 Formula: C27H35N3O3 Synonym: E 6446 Chemical Name: 6 [3 (pyrrolidin 1