Clofarabine nine 863405-60-1

863405-60-1

ZLN024 increases the activity of α1β1γ1 by 1

and downstream effectors

is an inverse agonist at the human cannabinoid CB1 receptor

InChiKey: SKYQTYQDKAOHLP-UHFFFAOYSA-N

Clofarabine nine 863405-60-1Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5' triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of